Sorbitol Dehydrogenase (SORD) (N-Term) Peptide
SORD
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN984237
Quick Overview for Sorbitol Dehydrogenase (SORD) (N-Term) Peptide (ABIN984237)
Target
SORD
(Sorbitol Dehydrogenase (SORD))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- ASGTVEKVGS SVKHLKPGDR VAIEPGAPRE NDEFCKMGRY NLSPSIFFCA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SORD Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SORD (Sorbitol Dehydrogenase (SORD))
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Background
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Sorbitol dehydrogenase (SORD, EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1, MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
Alias Symbols: SORD1
Protein Interaction Partner: SHBG,SORD,SORD
Protein Size: 357 -
Molecular Weight
- 38 kDa
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Gene ID
- 6652
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NCBI Accession
- NM_003104, NP_003095
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UniProt
- Q00796
Target
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